Experimental Evolution of an Oncolytic Vesicular Stomatitis Virus with Increased Selectivity for p53-Deficient Cells

Experimental evolution has been used for various biotechnological applications including protein and microbial cell engineering, but less commonly in the field of oncolytic virotherapy. Here, we sought to adapt a rapidly evolving RNA virus to cells deficient for the tumor suppressor gene p53, a hall...

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Detalles Bibliográficos
Autores principales: Garijo, Raquel, Hernández-Alonso, Pablo, Rivas, Carmen, Diallo, Jean-Simon, Sanjuán, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092128/
https://www.ncbi.nlm.nih.gov/pubmed/25010337
http://dx.doi.org/10.1371/journal.pone.0102365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092128/
https://www.ncbi.nlm.nih.gov/pubmed/25010337
http://dx.doi.org/10.1371/journal.pone.0102365

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