Widespread Sequence Variations in VAMP1 across Vertebrates Suggest a Potential Selective Pressure from Botulinum Neurotoxins

Botulinum neurotoxins (BoNT/A-G), the most potent toxins known, act by cleaving three SNARE proteins required for synaptic vesicle exocytosis. Previous studies on BoNTs have generally utilized the major SNARE homologues expressed in brain (VAMP2, syntaxin 1, and SNAP-25). However, BoNTs target perip...

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Detalles Bibliográficos
Autores principales: Peng, Lisheng, Adler, Michael, Demogines, Ann, Borrell, Andrew, Liu, Huisheng, Tao, Liang, Tepp, William H., Zhang, Su-Chun, Johnson, Eric A., Sawyer, Sara L., Dong, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092145/
https://www.ncbi.nlm.nih.gov/pubmed/25010769
http://dx.doi.org/10.1371/journal.ppat.1004177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092145/
https://www.ncbi.nlm.nih.gov/pubmed/25010769
http://dx.doi.org/10.1371/journal.ppat.1004177

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