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Intraventricular Topotecan for the Treatment of Neoplastic Meningitis: Five Case Studies
Many systemic cytotoxic agents cannot penetrate the blood-brain barrier. Because of this, in approximately 5% of cancer cases, metastatic disease is seen in the leptomeninges. Without treatment, patients with neoplastic meningitis (NM) generally survive for only a matter of weeks. In the treatment o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Harborside Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093345/ https://www.ncbi.nlm.nih.gov/pubmed/25031951 |
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author | Walker, Julie Schultz, Diana Grisdale, Kathleen Groves, Morris |
author_facet | Walker, Julie Schultz, Diana Grisdale, Kathleen Groves, Morris |
author_sort | Walker, Julie |
collection | PubMed |
description | Many systemic cytotoxic agents cannot penetrate the blood-brain barrier. Because of this, in approximately 5% of cancer cases, metastatic disease is seen in the leptomeninges. Without treatment, patients with neoplastic meningitis (NM) generally survive for only a matter of weeks. In the treatment of NM, intraventricular (IVT) topotecan results in progression-free and overall survival outcomes similar to those seen with other IVT chemotherapies, while being particularly well tolerated by most patients. In this article, we present the case studies of five patients with NM, with various primary malignancies, who received treatment with IVT topotecan. |
format | Online Article Text |
id | pubmed-4093345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Harborside Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40933452014-07-16 Intraventricular Topotecan for the Treatment of Neoplastic Meningitis: Five Case Studies Walker, Julie Schultz, Diana Grisdale, Kathleen Groves, Morris J Adv Pract Oncol Review Article Many systemic cytotoxic agents cannot penetrate the blood-brain barrier. Because of this, in approximately 5% of cancer cases, metastatic disease is seen in the leptomeninges. Without treatment, patients with neoplastic meningitis (NM) generally survive for only a matter of weeks. In the treatment of NM, intraventricular (IVT) topotecan results in progression-free and overall survival outcomes similar to those seen with other IVT chemotherapies, while being particularly well tolerated by most patients. In this article, we present the case studies of five patients with NM, with various primary malignancies, who received treatment with IVT topotecan. Harborside Press 2012 2012-07-01 /pmc/articles/PMC4093345/ /pubmed/25031951 Text en Copyright © 2012, Harborside Press http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited and is for non-commercial purposes. |
spellingShingle | Review Article Walker, Julie Schultz, Diana Grisdale, Kathleen Groves, Morris Intraventricular Topotecan for the Treatment of Neoplastic Meningitis: Five Case Studies |
title | Intraventricular Topotecan for the Treatment of Neoplastic Meningitis: Five Case Studies |
title_full | Intraventricular Topotecan for the Treatment of Neoplastic Meningitis: Five Case Studies |
title_fullStr | Intraventricular Topotecan for the Treatment of Neoplastic Meningitis: Five Case Studies |
title_full_unstemmed | Intraventricular Topotecan for the Treatment of Neoplastic Meningitis: Five Case Studies |
title_short | Intraventricular Topotecan for the Treatment of Neoplastic Meningitis: Five Case Studies |
title_sort | intraventricular topotecan for the treatment of neoplastic meningitis: five case studies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093345/ https://www.ncbi.nlm.nih.gov/pubmed/25031951 |
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