Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

BACKGROUND: Glioblastoma (GBM) is the most common malignant brain tumor in adults and is associated with a poor prognosis. Cytotoxic T lymphocyte antigen -4 (CTLA-4) blocking antibodies have demonstrated an ability to generate robust antitumor immune responses against a variety of solid tumors. 4-1B...

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Detalles Bibliográficos
Autores principales: Belcaid, Zineb, Phallen, Jillian A., Zeng, Jing, See, Alfred P., Mathios, Dimitrios, Gottschalk, Chelsea, Nicholas, Sarah, Kellett, Meghan, Ruzevick, Jacob, Jackson, Christopher, Albesiano, Emilia, Durham, Nicholas M., Ye, Xiaobu, Tran, Phuoc T., Tyler, Betty, Wong, John W., Brem, Henry, Pardoll, Drew M., Drake, Charles G., Lim, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094423/
https://www.ncbi.nlm.nih.gov/pubmed/25013914
http://dx.doi.org/10.1371/journal.pone.0101764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094423/
https://www.ncbi.nlm.nih.gov/pubmed/25013914
http://dx.doi.org/10.1371/journal.pone.0101764

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