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The Melatonin Agonist Ramelteon Induces Duration-Dependent Clock Gene Expression through cAMP Signaling in Pancreatic INS-1 β-Cells

Prolonged exposure to melatonin improves glycemic control in animals. Although glucose metabolism is controlled by circadian clock genes, little is known about the role of melatonin signaling and its duration in the regulation of clock gene expression in pancreatic β-cells. Activation of MT(1) and M...

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Detalles Bibliográficos
Autores principales: Nishiyama, Keiji, Hirai, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094524/
https://www.ncbi.nlm.nih.gov/pubmed/25013953
http://dx.doi.org/10.1371/journal.pone.0102073