Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential Virtual Screening

In this study, we have employed in silico methodology combining double pharmacophore based screening, molecular docking, and ADME/T filtering to identify dual binding site acetylcholinesterase inhibitors that can preferentially inhibit acetylcholinesterase and simultaneously inhibit the butyrylcholi...

Descripción completa

Detalles Bibliográficos
Autores principales: Gupta, Shikhar, Mohan, C. Gopi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094703/
https://www.ncbi.nlm.nih.gov/pubmed/25050335
http://dx.doi.org/10.1155/2014/291214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094703/
https://www.ncbi.nlm.nih.gov/pubmed/25050335
http://dx.doi.org/10.1155/2014/291214

Ejemplares similares