HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation

BACKGROUND: Interstitial fibrosis and fibrotic scar formation contribute to cardiac remodeling and loss of cardiac function in myocardial infarction (MI) and heart failure. Recent studies showed that histone deacetylase (HDAC) inhibitors retard fibrosis formation in acute MI settings. However, it is...

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Detalles Bibliográficos
Autores principales: Nural-Guvener, Hikmet F, Zakharova, Luidmila, Nimlos, James, Popovic, Snjezana, Mastroeni, Diego, Gaballa, Mohamed A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094898/
https://www.ncbi.nlm.nih.gov/pubmed/25024745
http://dx.doi.org/10.1186/1755-1536-7-10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094898/
https://www.ncbi.nlm.nih.gov/pubmed/25024745
http://dx.doi.org/10.1186/1755-1536-7-10

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