Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production

The production of recombinant proteins is frequently enhanced at the levels of transcription, codon usage, protein folding and secretion. Overproduction of heterologous proteins, however, also directly affects the primary metabolism of the producing cells. By incorporation of the production of a het...

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Detalles Bibliográficos
Autores principales: Nocon, Justyna, Steiger, Matthias G., Pfeffer, Martin, Sohn, Seung Bum, Kim, Tae Yong, Maurer, Michael, Rußmayer, Hannes, Pflügl, Stefan, Ask, Magnus, Haberhauer-Troyer, Christina, Ortmayr, Karin, Hann, Stephan, Koellensperger, Gunda, Gasser, Brigitte, Lee, Sang Yup, Mattanovich, Diethard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094982/
https://www.ncbi.nlm.nih.gov/pubmed/24853352
http://dx.doi.org/10.1016/j.ymben.2014.05.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094982/
https://www.ncbi.nlm.nih.gov/pubmed/24853352
http://dx.doi.org/10.1016/j.ymben.2014.05.011

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