Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium

INTRODUCTION: Acid-sensing ion channel 3 (ASIC3) is expressed in synoviocytes, activated by decreases in pH, and reduces inflammation in animal models of inflammatory arthritis. The purpose of the current study was to characterize potential mechanisms underlying the control of inflammation by ASIC3...

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Detalles Bibliográficos
Autores principales: Gong, Weiyi, Kolker, Sandra J, Usachev, Yuriy, Walder, Roxanne Y, Boyle, David L, Firestein, Gary S, Sluka, Kathleen A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095605/
https://www.ncbi.nlm.nih.gov/pubmed/24923411
http://dx.doi.org/10.1186/ar4577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095605/
https://www.ncbi.nlm.nih.gov/pubmed/24923411
http://dx.doi.org/10.1186/ar4577

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