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Suppression of the Oncogenic Transcription Factor FOXM1 by Proteasome Inhibitors
The oncogenic transcription factor FOXM1 is one of the key regulators of tumorigenesis. We found that FOXM1 upregulates its own transcription and its protein stability depends on its interaction with the chaperone nucleophosmin. We also determined that FOXM1 is negatively regulated by the tumor supp...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095980/ https://www.ncbi.nlm.nih.gov/pubmed/25093142 http://dx.doi.org/10.1155/2014/596528 |