Staufen1 dimerizes via a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay

Staufen (STAU)1-mediated mRNA decay (SMD) degrades mammalian-cell mRNAs that bind the double-stranded (ds)RNA-binding protein STAU1 in their 3′-untranslated region. We report a new motif, which typifies STAU homologs from all vertebrate classes, that is responsible for human (h)STAU1 homodimerizatio...

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Detalles Bibliográficos
Autores principales: Gleghorn, Michael L., Gong, Chenguang, Kielkopf, Clara L., Maquat, Lynne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096160/
https://www.ncbi.nlm.nih.gov/pubmed/23524536
http://dx.doi.org/10.1038/nsmb.2528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096160/
https://www.ncbi.nlm.nih.gov/pubmed/23524536
http://dx.doi.org/10.1038/nsmb.2528

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