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Staufen1 dimerizes via a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay
Staufen (STAU)1-mediated mRNA decay (SMD) degrades mammalian-cell mRNAs that bind the double-stranded (ds)RNA-binding protein STAU1 in their 3′-untranslated region. We report a new motif, which typifies STAU homologs from all vertebrate classes, that is responsible for human (h)STAU1 homodimerizatio...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096160/ https://www.ncbi.nlm.nih.gov/pubmed/23524536 http://dx.doi.org/10.1038/nsmb.2528 |