Cargando…

In Silico Investigation of Potential Pyruvate Kinase M2 Regulators from Traditional Chinese Medicine against Cancers

A recent research in cancer research demonstrates that tumor-specific pyruvate kinase M2 (PKM2) plays an important role in chromosome segregation and mitosis progression of tumor cells. To improve the drug development of TCM compounds, we aim to identify potent TCM compounds as lead compounds of PKM...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Kuan-Chung, Chen, Kuen-Bao, Chen, Hsin-Yi, Chen, Calvin Yu-Chian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096393/ https://www.ncbi.nlm.nih.gov/pubmed/25089263 http://dx.doi.org/10.1155/2014/189495

Ejemplares similares

In Silico Investigation of Potential mTOR Inhibitors from Traditional Chinese Medicine for Treatment of Leigh Syndrome
por: Chen, Kuan-Chung, et al.
Publicado: (2014)

In Silico Investigation of Potential TRAF6 Inhibitor from Traditional Chinese Medicine against Cancers
por: Chen, Kuan-Chung, et al.
Publicado: (2014)

Treatment of Cardiovascular Disease by Traditional Chinese Medicine against Pregnane X Receptor
por: Chen, Kuen-Bao, et al.
Publicado: (2014)

In Silico Investigation of Potential PARP-1 Inhibitors from Traditional Chinese Medicine
por: Chen, Kuan-Chung, et al.
Publicado: (2014)

In Silico Investigation of Potential Src Kinase Ligands from Traditional Chinese Medicine
por: Tou, Weng Ieong, et al.
Publicado: (2012)

In Silico Investigation of Traditional Chinese Medicine for Potential Lead Compounds as SPG7 Inhibitors against Coronary Artery Disease
por: Chen, Kuen-Bao, et al.
Publicado: (2016)

In Silico Design for Adenosine Monophosphate-Activated Protein Kinase Agonist from Traditional Chinese Medicine for Treatment of Metabolic Syndromes
por: Tang, Hsin-Chieh, et al.
Publicado: (2014)

In Silico Investigation of Traditional Chinese Medicine Compounds to Inhibit Human Histone Deacetylase 2 for Patients with Alzheimer's Disease
por: Hung, Tzu-Chieh, et al.
Publicado: (2014)

Treatment of Rheumatoid Arthritis with Traditional Chinese Medicine
por: Lee, Wen-Yuan, et al.
Publicado: (2014)

Potential Protein Phosphatase 2A Agents from Traditional Chinese Medicine against Cancer
por: Chen, Kuan-Chung, et al.
Publicado: (2014)

Ligand-Based and Structure-Based Investigation for Alzheimer's Disease from Traditional Chinese Medicine
por: Liao, Kai Hsin, et al.
Publicado: (2014)

In Silico Identification of Potent Pancreatic Triacylglycerol Lipase Inhibitors from Traditional Chinese Medicine
por: Chen, Kuan-Yu, et al.
Publicado: (2012)

In Silico Identification of Potent PPAR-γ Agonists from Traditional Chinese Medicine: A Bioactivity Prediction, Virtual Screening, and Molecular Dynamics Study
por: Chen, Kuan-Chung, et al.
Publicado: (2014)

Investigation of Potent Lead for Acquired Immunodeficiency Syndrome from Traditional Chinese Medicine
por: Hung, Tzu-Chieh, et al.
Publicado: (2014)

An Investigation of Small GTPases in relation to Liver Tumorigenesis Using Traditional Chinese Medicine
por: Hung, Tzu-Chieh, et al.
Publicado: (2014)

Investigation of Estrogen Receptor (ESR1) for Breast Cancer from Traditional Chinese Medicine
por: Hung, Tzu-Chieh, et al.
Publicado: (2014)

In Silico Investigation of Cytochrome P450 2C9 in relation to Aging Using Traditional Chinese Medicine
por: Hung, Tzu-Chieh, et al.
Publicado: (2014)

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico
por: Chen, Calvin Yu-Chian
Publicado: (2011)

Drug Design of Cyclin-Dependent Kinase 2 Inhibitor for Melanoma from Traditional Chinese Medicine
por: Tang, Hsin-Chieh, et al.
Publicado: (2014)

Potential Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Inhibitor from Traditional Chinese Medicine against Cancers
por: Lee, Wen-Yuan, et al.
Publicado: (2014)

Potential Smoothened Inhibitor from Traditional Chinese Medicine against the Disease of Diabetes, Obesity, and Cancer
por: Chen, Kuan-Chung, et al.
Publicado: (2014)

In Silico Design of BACE1 Inhibitor for Alzheimer's Disease by Traditional Chinese Medicine
por: Huang, Hung-Jin, et al.
Publicado: (2014)

Lead Screening for HIV-1 Integrase (IN) Inhibited by Traditional Chinese Medicine
por: Hung, Tzu-Chieh, et al.
Publicado: (2014)

Lead Screening for CXCR4 of the Human HIV Infection Receptor Inhibited by Traditional Chinese Medicine
por: Hung, Tzu-Chieh, et al.
Publicado: (2014)

The Inhibition of Folylpolyglutamate Synthetase (folC) in the Prevention of Drug Resistance in Mycobacterium tuberculosis by Traditional Chinese Medicine
por: Hung, Tzu-Chieh, et al.
Publicado: (2014)

Lead Screening for HIV of C-C Chemokine Receptor Type 5 Receptor Inhibited by Traditional Chinese Medicine
por: Hung, Tzu-Chieh, et al.
Publicado: (2014)

Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine
por: Hung, Tzu-Chieh, et al.
Publicado: (2014)

Potential Retinoid X Receptor Agonists for Treating Alzheimer's Disease from Traditional Chinese Medicine
por: Chen, Kuan-Chung, et al.
Publicado: (2014)

Possible Inhibitor from Traditional Chinese Medicine for the β Form of Calcium-Dependent Protein Kinase Type II in the Treatment of Major Depressive Disorder
por: Hung, Tzu-Chieh, et al.
Publicado: (2014)

Design of Glucagon-Like Peptide-1 Receptor Agonist for Diabetes Mellitus from Traditional Chinese Medicine
por: Tang, Hsin-Chieh, et al.
Publicado: (2014)

Uroporphyrinogen Decarboxylase as a Potential Target for Specific Components of Traditional Chinese Medicine: A Virtual Screening and Molecular Dynamics Study
por: Tsou, Yung-An, et al.
Publicado: (2012)

Computational Design of Apolipoprotein E4 Inhibitors for Alzheimer's Disease Therapy from Traditional Chinese Medicine
por: Huang, Hung-Jin, et al.
Publicado: (2014)

When Modern Technology Meets Ancient Traditional Chinese Medicine
por: Chen, Calvin Yu-Chian, et al.
Publicado: (2015)

Finding Inhibitors of Mutant Superoxide Dismutase-1 for Amyotrophic Lateral Sclerosis Therapy from Traditional Chinese Medicine
por: Huang, Hung-Jin, et al.
Publicado: (2014)

Identification of tyrosinase inhibitors from traditional Chinese medicines for the management of hyperpigmentation
por: Tang, Hsin-Chieh, et al.
Publicado: (2015)

Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine
por: Hsiao, Ya-Li, et al.
Publicado: (2014)

Drug Design for Neuropathic Pain Regulation from Traditional Chinese Medicine
por: Tou, Weng Ieong, et al.
Publicado: (2013)

SH2 domain-containing phosphatase 1 regulates pyruvate kinase M2 in hepatocellular carcinoma
por: Tai, Wei-Tien, et al.
Publicado: (2016)

Pharmacological Chaperone Design for Reducing Risk Factor of Parkinson's Disease from Traditional Chinese Medicine
por: Huang, Hung-Jin, et al.
Publicado: (2014)

Lead Discovery for Alzheimer's Disease Related Target Protein RbAp48 from Traditional Chinese Medicine
por: Huang, Hung-Jin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_7fm1r6kf23dnug9q78lvni2rut