Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis

The primary cilium originates from the mother centriole and participates in critical functions during organogenesis. Defects in cilia biogenesis or function lead to pleiotropic phenotypes. Mutations in centrosome-cilia gene CC2D2A result in Meckel and Joubert syndromes. Here we generate a Cc2d2a(-/-...

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Detalles Bibliográficos
Autores principales: Veleri, Shobi, Manjunath, Souparnika H., Fariss, Robert N., May-Simera, Helen, Brooks, Matthew, Foskett, Trevor A., Gao, Chun, Longo, Teresa A., Liu, Pinghu, Nagashima, Kunio, Rachel, Rivka A., Li, Tiansen, Dong, Lijin, Swaroop, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096663/
https://www.ncbi.nlm.nih.gov/pubmed/24947469
http://dx.doi.org/10.1038/ncomms5207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096663/
https://www.ncbi.nlm.nih.gov/pubmed/24947469
http://dx.doi.org/10.1038/ncomms5207

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