High scFv-receptor affinity does not enhance the antitumor activity of HER2 retargeted measles virus

The relationship between ligand-receptor affinity and antitumor potency of an oncolytic virus was investigated using a panel of six HER2/neu (HER2) targeted measles viruses (MV) displaying single-chain antibodies (scFv) that bind to the same epitope on HER2, but with affinities ranging from 10(−6) t...

Descripción completa

Detalles Bibliográficos
Autores principales: Suksanpaisan, Lukkana, Russell, Stephen J, Peng, Kah-Whye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096840/
https://www.ncbi.nlm.nih.gov/pubmed/24874841
http://dx.doi.org/10.1038/cgt.2014.25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096840/
https://www.ncbi.nlm.nih.gov/pubmed/24874841
http://dx.doi.org/10.1038/cgt.2014.25

Ejemplares similares