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High scFv-receptor affinity does not enhance the antitumor activity of HER2 retargeted measles virus
The relationship between ligand-receptor affinity and antitumor potency of an oncolytic virus was investigated using a panel of six HER2/neu (HER2) targeted measles viruses (MV) displaying single-chain antibodies (scFv) that bind to the same epitope on HER2, but with affinities ranging from 10(−6) t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096840/ https://www.ncbi.nlm.nih.gov/pubmed/24874841 http://dx.doi.org/10.1038/cgt.2014.25 |