Effects of high-fat diet and the anti-diabetic drug metformin on circulating GLP-1 and the relative number of intestinal L-cells

BACKGROUND: Elevated serum free fatty acids (FFAs) contribute to the pathogenesis of type-2-diabetes (T2D), and lipotoxicity is observed in many cell types. We recently showed that simulated hyperlipidemia induces lipoapoptosis also in GLP-1-secreting L-cells in vitro, while metformin confers lipopr...

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Detalles Bibliográficos
Autores principales: Kappe, Camilla, Zhang, Qimin, Nyström, Thomas, Sjöholm, Åke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097088/
https://www.ncbi.nlm.nih.gov/pubmed/25028601
http://dx.doi.org/10.1186/1758-5996-6-70

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097088/
https://www.ncbi.nlm.nih.gov/pubmed/25028601
http://dx.doi.org/10.1186/1758-5996-6-70

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