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Effects of high-fat diet and the anti-diabetic drug metformin on circulating GLP-1 and the relative number of intestinal L-cells

BACKGROUND: Elevated serum free fatty acids (FFAs) contribute to the pathogenesis of type-2-diabetes (T2D), and lipotoxicity is observed in many cell types. We recently showed that simulated hyperlipidemia induces lipoapoptosis also in GLP-1-secreting L-cells in vitro, while metformin confers lipopr...

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Detalles Bibliográficos
Autores principales:	Kappe, Camilla, Zhang, Qimin, Nyström, Thomas, Sjöholm, Åke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097088/ https://www.ncbi.nlm.nih.gov/pubmed/25028601 http://dx.doi.org/10.1186/1758-5996-6-70

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