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Physiological and pathological phosphorylation of tau by Cdk5

Hyperphosphorylation of microtubule-associated protein tau is one of the major pathological events in Alzheimer’s disease (AD) and other related neurodegenerative diseases, including frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17). Mutations in the tau gene MAPT are a cau...

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Detalles Bibliográficos
Autores principales: Kimura, Taeko, Ishiguro, Koichi, Hisanaga, Shin-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097945/
https://www.ncbi.nlm.nih.gov/pubmed/25076872
http://dx.doi.org/10.3389/fnmol.2014.00065