Bronchoalveolar Lavage Fluid Utilized Ex Vivo to Validate In Vivo Findings: Inhibition of Gap Junction Activity in Lung Tumor Promotion is Toll-Like Receptor 4-Dependent

TLR4 protects against lung tumor promotion and pulmonary inflammation in mice. Connexin 43 (Cx43), a gap junction gene, was increased in Tlr4 wildtype compared to Tlr4-mutant mice in response to promotion, which suggests gap junctional intercellular communication (GJIC) may be compromised. We hypoth...

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Detalles Bibliográficos
Autores principales: Hill, Thomas, Osgood, Ross S, Velmurugan, Kalpana, Alexander, Carla-Maria, Upham, Brad L, Bauer, Alison K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098145/
https://www.ncbi.nlm.nih.gov/pubmed/25035812
http://dx.doi.org/10.4172/2155-9929.1000160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098145/
https://www.ncbi.nlm.nih.gov/pubmed/25035812
http://dx.doi.org/10.4172/2155-9929.1000160

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