Effective filtering strategies to improve data quality from population-based whole exome sequencing studies

BACKGROUND: Genotypes generated in next generation sequencing studies contain errors which can significantly impact the power to detect signals in common and rare variant association tests. These genotyping errors are not explicitly filtered by the standard GATK Variant Quality Score Recalibration (...

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Detalles Bibliográficos
Autores principales: Carson, Andrew R, Smith, Erin N, Matsui, Hiroko, Brækkan, Sigrid K, Jepsen, Kristen, Hansen, John-Bjarne, Frazer, Kelly A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098776/
https://www.ncbi.nlm.nih.gov/pubmed/24884706
http://dx.doi.org/10.1186/1471-2105-15-125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098776/
https://www.ncbi.nlm.nih.gov/pubmed/24884706
http://dx.doi.org/10.1186/1471-2105-15-125

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