Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to Vpx(MAC) induced ubiquitination and proteasomal degradation

BACKGROUND: The deoxynucleotide-triphosphate (dNTP) hydrolase sterile alpha motif domain and HD domain 1 (SAMHD1) is a nuclear protein that inhibits HIV-1 infection in myeloid cells as well as quiescent CD4 T-cells, by decreasing the intracellular dNTP concentration below a level that is required fo...

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Detalles Bibliográficos
Autores principales: Schaller, Torsten, Pollpeter, Darja, Apolonia, Luis, Goujon, Caroline, Malim, Michael H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098787/
https://www.ncbi.nlm.nih.gov/pubmed/24712655
http://dx.doi.org/10.1186/1742-4690-11-29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098787/
https://www.ncbi.nlm.nih.gov/pubmed/24712655
http://dx.doi.org/10.1186/1742-4690-11-29

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