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Chronopharmacodynamics and Chronopharmacokinetics of Pethidine in Mice

BACKGROUND: Many studies have demonstrated that the pharmacokinetics and pharmacodynamics of analgesic drugs vary according to the circadian time of drug administration. This study aims at determining whether the analgesic effect and pharmacokinetics of pethidine in male BALB/c mice are influenced b...

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Detalles Bibliográficos
Autores principales: Zhang, Chengliang, Yu, Zaoqin, Li, Xiping, Xu, Yanjiao, Liu, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098901/
https://www.ncbi.nlm.nih.gov/pubmed/25025283
http://dx.doi.org/10.1371/journal.pone.0102054