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Chronopharmacodynamics and Chronopharmacokinetics of Pethidine in Mice
BACKGROUND: Many studies have demonstrated that the pharmacokinetics and pharmacodynamics of analgesic drugs vary according to the circadian time of drug administration. This study aims at determining whether the analgesic effect and pharmacokinetics of pethidine in male BALB/c mice are influenced b...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098901/ https://www.ncbi.nlm.nih.gov/pubmed/25025283 http://dx.doi.org/10.1371/journal.pone.0102054 |