Directed Evolution of an LBP/CD14 Inhibitory Peptide and Its Anti-Endotoxin Activity

BACKGROUND: LPS-binding protein (LBP) and its ligand CD14 are located upstream of the signaling pathway for LPS-induced inflammation. Blocking LBP and CD14 binding might prevent LPS-induced inflammation. In previous studies, we obtained a peptide analog (MP12) for the LBP/CD14 binding site and showe...

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Detalles Bibliográficos
Autores principales: Fang, Li, Xu, Zhi, Wang, Guan-song, Ji, Fu-yun, Mei, Chun-xia, Liu, Juan, Wu, Guo-ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098906/
https://www.ncbi.nlm.nih.gov/pubmed/25025695
http://dx.doi.org/10.1371/journal.pone.0101406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098906/
https://www.ncbi.nlm.nih.gov/pubmed/25025695
http://dx.doi.org/10.1371/journal.pone.0101406

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