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Directed Evolution of an LBP/CD14 Inhibitory Peptide and Its Anti-Endotoxin Activity
BACKGROUND: LPS-binding protein (LBP) and its ligand CD14 are located upstream of the signaling pathway for LPS-induced inflammation. Blocking LBP and CD14 binding might prevent LPS-induced inflammation. In previous studies, we obtained a peptide analog (MP12) for the LBP/CD14 binding site and showe...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098906/ https://www.ncbi.nlm.nih.gov/pubmed/25025695 http://dx.doi.org/10.1371/journal.pone.0101406 |