Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia

Oxidative stress contributes to genomic instability in chronic lymphocytic leukemia (CLL), but its relationship with the acquisition of specific chromosomal abnormalities is unknown. We recruited 55 untreated CLL patients and assessed 8-oxo-2′-deoxyguanosine (8-oxo-dG), glutathione, and malondialdeh...

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Autores principales: Collado, Rosa, Ivars, David, Oliver, Isabel, Tormos, Carmen, Egea, Mercedes, Miguel, Amparo, Sáez, Guillermo T., Carbonell, Félix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099055/
https://www.ncbi.nlm.nih.gov/pubmed/25054143
http://dx.doi.org/10.1155/2014/686392
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author Collado, Rosa
Ivars, David
Oliver, Isabel
Tormos, Carmen
Egea, Mercedes
Miguel, Amparo
Sáez, Guillermo T.
Carbonell, Félix
author_facet Collado, Rosa
Ivars, David
Oliver, Isabel
Tormos, Carmen
Egea, Mercedes
Miguel, Amparo
Sáez, Guillermo T.
Carbonell, Félix
author_sort Collado, Rosa
collection PubMed
description Oxidative stress contributes to genomic instability in chronic lymphocytic leukemia (CLL), but its relationship with the acquisition of specific chromosomal abnormalities is unknown. We recruited 55 untreated CLL patients and assessed 8-oxo-2′-deoxyguanosine (8-oxo-dG), glutathione, and malondialdehyde (MDA) levels, and we compared them among the cytogenetic subgroups established using fluorescence in situ hybridization (FISH). Significant increases in 8-oxo-dG and/or MDA were observed in patients with unfavorable cytogenetic aberrations (17p and 11q deletions) compared to the 13q deletion group. TP53 deletion patients exhibited a diminished DNA repair efficiency. Finally, cases with normal FISH also showed enhanced 8-oxo-dG, which could result in adverse outcomes.
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spelling pubmed-40990552014-07-22 Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia Collado, Rosa Ivars, David Oliver, Isabel Tormos, Carmen Egea, Mercedes Miguel, Amparo Sáez, Guillermo T. Carbonell, Félix Biomed Res Int Research Article Oxidative stress contributes to genomic instability in chronic lymphocytic leukemia (CLL), but its relationship with the acquisition of specific chromosomal abnormalities is unknown. We recruited 55 untreated CLL patients and assessed 8-oxo-2′-deoxyguanosine (8-oxo-dG), glutathione, and malondialdehyde (MDA) levels, and we compared them among the cytogenetic subgroups established using fluorescence in situ hybridization (FISH). Significant increases in 8-oxo-dG and/or MDA were observed in patients with unfavorable cytogenetic aberrations (17p and 11q deletions) compared to the 13q deletion group. TP53 deletion patients exhibited a diminished DNA repair efficiency. Finally, cases with normal FISH also showed enhanced 8-oxo-dG, which could result in adverse outcomes. Hindawi Publishing Corporation 2014 2014-06-26 /pmc/articles/PMC4099055/ /pubmed/25054143 http://dx.doi.org/10.1155/2014/686392 Text en Copyright © 2014 Rosa Collado et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Collado, Rosa
Ivars, David
Oliver, Isabel
Tormos, Carmen
Egea, Mercedes
Miguel, Amparo
Sáez, Guillermo T.
Carbonell, Félix
Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia
title Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia
title_full Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia
title_fullStr Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia
title_full_unstemmed Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia
title_short Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia
title_sort increased oxidative damage associated with unfavorable cytogenetic subgroups in chronic lymphocytic leukemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099055/
https://www.ncbi.nlm.nih.gov/pubmed/25054143
http://dx.doi.org/10.1155/2014/686392
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