Inactivating UBE2M Impacts the DNA Damage Response and Genome Integrity Involving Multiple Cullin Ligases

Protein neddylation is involved in a wide variety of cellular processes. Here we show that the DNA damage response is perturbed in cells inactivated with an E2 Nedd8 conjugating enzyme UBE2M, measured by RAD51 foci formation kinetics and cell based DNA repair assays. UBE2M knockdown increases DNA br...

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Detalles Bibliográficos
Autores principales: Cukras, Scott, Morffy, Nicholas, Ohn, Takbum, Kee, Younghoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099125/
https://www.ncbi.nlm.nih.gov/pubmed/25025768
http://dx.doi.org/10.1371/journal.pone.0101844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099125/
https://www.ncbi.nlm.nih.gov/pubmed/25025768
http://dx.doi.org/10.1371/journal.pone.0101844

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