Establishment of a Structure–Activity Relationship of 1H-Imidazo[4,5-c]quinoline-Based Kinase Inhibitor NVP-BEZ235 as a Lead for African Sleeping Sickness

[Image: see text] Compound NVP-BEZ235 (1) is a potent inhibitor of human phospoinositide-3-kinases and mammalian target of rapamycin (mTOR) that also showed high inhibitory potency against Trypanosoma brucei cultures. With an eye toward using 1 as a starting point for anti-trypanosomal drug discover...

Descripción completa

Detalles Bibliográficos
Autores principales: Seixas, João D., Luengo-Arratta, Sandra A., Diaz, Rosario, Saldivia, Manuel, Rojas-Barros, Domingo I., Manzano, Pilar, Gonzalez, Silvia, Berlanga, Manuela, Smith, Terry K., Navarro, Miguel, Pollastri, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099174/
https://www.ncbi.nlm.nih.gov/pubmed/24805946
http://dx.doi.org/10.1021/jm500361r

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099174/
https://www.ncbi.nlm.nih.gov/pubmed/24805946
http://dx.doi.org/10.1021/jm500361r

Ejemplares similares