Comparing Binding Modes of Analogous Fragments Using NMR in Fragment-Based Drug Design: Application to PRDX5

Fragment-based drug design is one of the most promising approaches for discovering novel and potent inhibitors against therapeutic targets. The first step of the process consists of identifying fragments that bind the protein target. The determination of the fragment binding mode plays a major role...

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Detalles Bibliográficos
Autores principales: Aguirre, Clémentine, Brink, Tim ten, Guichou, Jean-François, Cala, Olivier, Krimm, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099364/
https://www.ncbi.nlm.nih.gov/pubmed/25025339
http://dx.doi.org/10.1371/journal.pone.0102300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099364/
https://www.ncbi.nlm.nih.gov/pubmed/25025339
http://dx.doi.org/10.1371/journal.pone.0102300

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