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Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection()()
GLP-1R agonists improve outcomes in ischemic heart disease. Here we studied GLP-1R-dependent adaptive and cardioprotective responses to ventricular injury. Glp1r(−/−) hearts exhibited chamber-specific differences in gene expression, but normal mortality and left ventricular (LV) remodeling after myo...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099509/ https://www.ncbi.nlm.nih.gov/pubmed/25061556 http://dx.doi.org/10.1016/j.molmet.2014.04.009 |