Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling

(6R)-5,6,7,8-Tetrahydro-l-biopterin (BH4) availability regulates nitric oxide and superoxide formation by endothelial nitric oxide synthase (eNOS). At low BH4 or low BH4 to 7,8-dihydrobiopterin (BH2) ratios the enzyme becomes uncoupled and generates superoxide at the expense of NO. We studied the ef...

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Detalles Bibliográficos
Autores principales: Schmidt, Kurt, Kolesnik, Bernd, Gorren, Antonius C.F., Werner, Ernst R., Mayer, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099517/
https://www.ncbi.nlm.nih.gov/pubmed/24863258
http://dx.doi.org/10.1016/j.bcp.2014.05.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099517/
https://www.ncbi.nlm.nih.gov/pubmed/24863258
http://dx.doi.org/10.1016/j.bcp.2014.05.010

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