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MMSET: Role and Therapeutic Opportunities in Multiple Myeloma
Recurrent chromosomal translocations are central to the pathogenesis, diagnosis, and prognosis of hematologic malignancies. The translocation t(4; 14)(p16; q32) is one of the most common translocations in multiple myeloma (MM) and is associated with very poor prognosis. The t(4; 14) translocation le...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100374/ https://www.ncbi.nlm.nih.gov/pubmed/25093175 http://dx.doi.org/10.1155/2014/636514 |
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author | Xie, Zhigang Chng, Wee Joo |
author_facet | Xie, Zhigang Chng, Wee Joo |
author_sort | Xie, Zhigang |
collection | PubMed |
description | Recurrent chromosomal translocations are central to the pathogenesis, diagnosis, and prognosis of hematologic malignancies. The translocation t(4; 14)(p16; q32) is one of the most common translocations in multiple myeloma (MM) and is associated with very poor prognosis. The t(4; 14) translocation leads to the simultaneous overexpression of two genes, FGFR3 (fibroblast growth factor receptor 3) and MMSET (multiple myeloma SET domain), both of which have potential oncogenic activity. However, approximately 30% of t(4; 14) MM patients do not express FGFR3 and have poor prognosis irrespective of FGFR3 expression, whereas MMSET overexpression is universal in t(4; 14) cases. In this review, we provide an overview of recent findings regarding the oncogenic roles of MMSET in MM and its functions on histone methylation. We also highlight some of MMSET partners and its downstream signalling pathways and discuss the potential therapeutics targeting MMSET. |
format | Online Article Text |
id | pubmed-4100374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41003742014-08-04 MMSET: Role and Therapeutic Opportunities in Multiple Myeloma Xie, Zhigang Chng, Wee Joo Biomed Res Int Review Article Recurrent chromosomal translocations are central to the pathogenesis, diagnosis, and prognosis of hematologic malignancies. The translocation t(4; 14)(p16; q32) is one of the most common translocations in multiple myeloma (MM) and is associated with very poor prognosis. The t(4; 14) translocation leads to the simultaneous overexpression of two genes, FGFR3 (fibroblast growth factor receptor 3) and MMSET (multiple myeloma SET domain), both of which have potential oncogenic activity. However, approximately 30% of t(4; 14) MM patients do not express FGFR3 and have poor prognosis irrespective of FGFR3 expression, whereas MMSET overexpression is universal in t(4; 14) cases. In this review, we provide an overview of recent findings regarding the oncogenic roles of MMSET in MM and its functions on histone methylation. We also highlight some of MMSET partners and its downstream signalling pathways and discuss the potential therapeutics targeting MMSET. Hindawi Publishing Corporation 2014 2014-07-01 /pmc/articles/PMC4100374/ /pubmed/25093175 http://dx.doi.org/10.1155/2014/636514 Text en Copyright © 2014 Z. Xie and W. J. Chng. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Xie, Zhigang Chng, Wee Joo MMSET: Role and Therapeutic Opportunities in Multiple Myeloma |
title | MMSET: Role and Therapeutic Opportunities in Multiple Myeloma |
title_full | MMSET: Role and Therapeutic Opportunities in Multiple Myeloma |
title_fullStr | MMSET: Role and Therapeutic Opportunities in Multiple Myeloma |
title_full_unstemmed | MMSET: Role and Therapeutic Opportunities in Multiple Myeloma |
title_short | MMSET: Role and Therapeutic Opportunities in Multiple Myeloma |
title_sort | mmset: role and therapeutic opportunities in multiple myeloma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100374/ https://www.ncbi.nlm.nih.gov/pubmed/25093175 http://dx.doi.org/10.1155/2014/636514 |
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