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MMSET: Role and Therapeutic Opportunities in Multiple Myeloma

Recurrent chromosomal translocations are central to the pathogenesis, diagnosis, and prognosis of hematologic malignancies. The translocation t(4; 14)(p16; q32) is one of the most common translocations in multiple myeloma (MM) and is associated with very poor prognosis. The t(4; 14) translocation le...

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Detalles Bibliográficos
Autores principales: Xie, Zhigang, Chng, Wee Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100374/
https://www.ncbi.nlm.nih.gov/pubmed/25093175
http://dx.doi.org/10.1155/2014/636514
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author Xie, Zhigang
Chng, Wee Joo
author_facet Xie, Zhigang
Chng, Wee Joo
author_sort Xie, Zhigang
collection PubMed
description Recurrent chromosomal translocations are central to the pathogenesis, diagnosis, and prognosis of hematologic malignancies. The translocation t(4; 14)(p16; q32) is one of the most common translocations in multiple myeloma (MM) and is associated with very poor prognosis. The t(4; 14) translocation leads to the simultaneous overexpression of two genes, FGFR3 (fibroblast growth factor receptor 3) and MMSET (multiple myeloma SET domain), both of which have potential oncogenic activity. However, approximately 30% of t(4; 14) MM patients do not express FGFR3 and have poor prognosis irrespective of FGFR3 expression, whereas MMSET overexpression is universal in t(4; 14) cases. In this review, we provide an overview of recent findings regarding the oncogenic roles of MMSET in MM and its functions on histone methylation. We also highlight some of MMSET partners and its downstream signalling pathways and discuss the potential therapeutics targeting MMSET.
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spelling pubmed-41003742014-08-04 MMSET: Role and Therapeutic Opportunities in Multiple Myeloma Xie, Zhigang Chng, Wee Joo Biomed Res Int Review Article Recurrent chromosomal translocations are central to the pathogenesis, diagnosis, and prognosis of hematologic malignancies. The translocation t(4; 14)(p16; q32) is one of the most common translocations in multiple myeloma (MM) and is associated with very poor prognosis. The t(4; 14) translocation leads to the simultaneous overexpression of two genes, FGFR3 (fibroblast growth factor receptor 3) and MMSET (multiple myeloma SET domain), both of which have potential oncogenic activity. However, approximately 30% of t(4; 14) MM patients do not express FGFR3 and have poor prognosis irrespective of FGFR3 expression, whereas MMSET overexpression is universal in t(4; 14) cases. In this review, we provide an overview of recent findings regarding the oncogenic roles of MMSET in MM and its functions on histone methylation. We also highlight some of MMSET partners and its downstream signalling pathways and discuss the potential therapeutics targeting MMSET. Hindawi Publishing Corporation 2014 2014-07-01 /pmc/articles/PMC4100374/ /pubmed/25093175 http://dx.doi.org/10.1155/2014/636514 Text en Copyright © 2014 Z. Xie and W. J. Chng. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xie, Zhigang
Chng, Wee Joo
MMSET: Role and Therapeutic Opportunities in Multiple Myeloma
title MMSET: Role and Therapeutic Opportunities in Multiple Myeloma
title_full MMSET: Role and Therapeutic Opportunities in Multiple Myeloma
title_fullStr MMSET: Role and Therapeutic Opportunities in Multiple Myeloma
title_full_unstemmed MMSET: Role and Therapeutic Opportunities in Multiple Myeloma
title_short MMSET: Role and Therapeutic Opportunities in Multiple Myeloma
title_sort mmset: role and therapeutic opportunities in multiple myeloma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100374/
https://www.ncbi.nlm.nih.gov/pubmed/25093175
http://dx.doi.org/10.1155/2014/636514
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