Phase I/II Clinical Trial of Encapsulated, Cytochrome P450 Expressing Cells as Local Activators of Cyclophosphamide to Treat Spontaneous Canine Tumours

Based upon promising preclinical studies, a clinical trial was performed in which encapsulated cells overexpressing cytochrome P450 enzyme isoform 2B1 were implanted around malignant mammary tumours arising spontaneously in dogs. The dogs were then given cyclophosphamide, one of the standard chemoth...

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Detalles Bibliográficos
Autores principales: Michałowska, Monika, Winiarczyk, Stanislaw, Adaszek, Łukasz, Łopuszyński, Wojciech, Grądzki, Zbigniew, Salmons, Brian, Günzburg, Walter H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100764/
https://www.ncbi.nlm.nih.gov/pubmed/25028963
http://dx.doi.org/10.1371/journal.pone.0102061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100764/
https://www.ncbi.nlm.nih.gov/pubmed/25028963
http://dx.doi.org/10.1371/journal.pone.0102061

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