A sodium-mediated structural switch that controls the sensitivity of Kir channels to PIP(2)

Inwardly rectifying potassium (Kir) channels are gated by the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PIP(2)). Among them, Kir3 channel gating requires additional molecules, such as the βγ subunits of G proteins or intracellular sodium. Using an interactive computational-experim...

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Detalles Bibliográficos
Autores principales: Rosenhouse-Dantsker, Avia, Sui, Jin L., Zhao, Qi, Rusinova, Radda, Rodríguez-Menchaca, Aldo A., Zhang, Zhe, Logothetis, Diomedes E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100997/
https://www.ncbi.nlm.nih.gov/pubmed/18794864
http://dx.doi.org/10.1038/nchembio.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100997/
https://www.ncbi.nlm.nih.gov/pubmed/18794864
http://dx.doi.org/10.1038/nchembio.112

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