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A sodium-mediated structural switch that controls the sensitivity of Kir channels to PIP(2)

Inwardly rectifying potassium (Kir) channels are gated by the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PIP(2)). Among them, Kir3 channel gating requires additional molecules, such as the βγ subunits of G proteins or intracellular sodium. Using an interactive computational-experim...

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Detalles Bibliográficos
Autores principales:	Rosenhouse-Dantsker, Avia, Sui, Jin L., Zhao, Qi, Rusinova, Radda, Rodríguez-Menchaca, Aldo A., Zhang, Zhe, Logothetis, Diomedes E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100997/ https://www.ncbi.nlm.nih.gov/pubmed/18794864 http://dx.doi.org/10.1038/nchembio.112

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