The Ca(2+)-activated Cl(−) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis

Since anoctamin 1 ANO1 (TMEM16A) was found to be a molecular component of Ca(2+)-activated Cl(−) channels, its role in tumorigenesis has gained attention at a fast pace. ANO1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many type...

Descripción completa

Detalles Bibliográficos
Autores principales: Qu, Zhiqiang, Yao, Weicheng, Yao, Ruyong, Liu, Xiangping, Yu, Kuai, Hartzell, Criss
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101736/
https://www.ncbi.nlm.nih.gov/pubmed/24639373
http://dx.doi.org/10.1002/cam4.232
_version_ 1782480944994713600
author Qu, Zhiqiang
Yao, Weicheng
Yao, Ruyong
Liu, Xiangping
Yu, Kuai
Hartzell, Criss
author_facet Qu, Zhiqiang
Yao, Weicheng
Yao, Ruyong
Liu, Xiangping
Yu, Kuai
Hartzell, Criss
author_sort Qu, Zhiqiang
collection PubMed
description Since anoctamin 1 ANO1 (TMEM16A) was found to be a molecular component of Ca(2+)-activated Cl(−) channels, its role in tumorigenesis has gained attention at a fast pace. ANO1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. ANO1 is now considered an excellent biomarker for certain cancers. Recent research suggests that it is the channel function of ANO1 that is involved in the tumorigenesis. However, how the overexpression of the functional ANO1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated. Clarification of the reasons in future will avail to make ANO1 as a target for cancer treatment.
format Online
Article
Text
id pubmed-4101736
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BlackWell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-41017362014-07-28 The Ca(2+)-activated Cl(−) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis Qu, Zhiqiang Yao, Weicheng Yao, Ruyong Liu, Xiangping Yu, Kuai Hartzell, Criss Cancer Med Reviews Since anoctamin 1 ANO1 (TMEM16A) was found to be a molecular component of Ca(2+)-activated Cl(−) channels, its role in tumorigenesis has gained attention at a fast pace. ANO1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. ANO1 is now considered an excellent biomarker for certain cancers. Recent research suggests that it is the channel function of ANO1 that is involved in the tumorigenesis. However, how the overexpression of the functional ANO1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated. Clarification of the reasons in future will avail to make ANO1 as a target for cancer treatment. BlackWell Publishing Ltd 2014-06 2014-03-18 /pmc/articles/PMC4101736/ /pubmed/24639373 http://dx.doi.org/10.1002/cam4.232 Text en © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Qu, Zhiqiang
Yao, Weicheng
Yao, Ruyong
Liu, Xiangping
Yu, Kuai
Hartzell, Criss
The Ca(2+)-activated Cl(−) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis
title The Ca(2+)-activated Cl(−) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis
title_full The Ca(2+)-activated Cl(−) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis
title_fullStr The Ca(2+)-activated Cl(−) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis
title_full_unstemmed The Ca(2+)-activated Cl(−) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis
title_short The Ca(2+)-activated Cl(−) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis
title_sort ca(2+)-activated cl(−) channel, ano1 (tmem16a), is a double-edged sword in cell proliferation and tumorigenesis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101736/
https://www.ncbi.nlm.nih.gov/pubmed/24639373
http://dx.doi.org/10.1002/cam4.232
work_keys_str_mv AT quzhiqiang theca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis
AT yaoweicheng theca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis
AT yaoruyong theca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis
AT liuxiangping theca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis
AT yukuai theca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis
AT hartzellcriss theca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis
AT quzhiqiang ca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis
AT yaoweicheng ca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis
AT yaoruyong ca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis
AT liuxiangping ca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis
AT yukuai ca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis
AT hartzellcriss ca2activatedclchannelano1tmem16aisadoubleedgedswordincellproliferationandtumorigenesis

Ejemplares similares