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Decreased decorin expression in the tumor microenvironment

Decorin is a small leucine-rich proteoglycan, synthesized and deposited by fibroblasts in the stroma where it binds to collagen I. It sequesters several growth factors and antagonizes numerous members of the receptor tyrosine kinase family. In experimental murine systems, it acted as a potent tumor...

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Detalles Bibliográficos
Autores principales: Bozoky, Benedek, Savchenko, Andrii, Guven, Hayrettin, Ponten, Fredrik, Klein, George, Szekely, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101739/
https://www.ncbi.nlm.nih.gov/pubmed/24634138
http://dx.doi.org/10.1002/cam4.231