Enzyme 15-lipoxygenase 1 promotes hypoxia-inducible factor 1α turnover and reduces vascular endothelial growth factor expression: implications for angiogenesis

Hypoxia-inducible factor 1α (HIF-1α) is the regulatory subunit of the heterodimeric HIF-1 that plays a critical role in transcriptional regulation of genes in angiogenesis and hypoxic adaptation, while fatty acid metabolism mediated by lipoxygenases has been implicated in a variety of pathogeneses,...

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Detalles Bibliográficos
Autores principales: Zhong, Hua, Wang, Ruoxiang, Kelavkar, Uddhav, Wang, Christopher Y, Simons, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101742/
https://www.ncbi.nlm.nih.gov/pubmed/24668884
http://dx.doi.org/10.1002/cam4.227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101742/
https://www.ncbi.nlm.nih.gov/pubmed/24668884
http://dx.doi.org/10.1002/cam4.227

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