A mechanistic stress model of protein evolution accounts for site-specific evolutionary rates and their relationship with packing density and flexibility

BACKGROUND: Protein sites evolve at different rates due to functional and biophysical constraints. It is usually considered that the main structural determinant of a site’s rate of evolution is its Relative Solvent Accessibility (RSA). However, a recent comparative study has shown that the main stru...

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Detalles Bibliográficos
Autores principales: Huang, Tsun-Tsao, del Valle Marcos, María Laura, Hwang, Jenn-Kang, Echave, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101840/
https://www.ncbi.nlm.nih.gov/pubmed/24716445
http://dx.doi.org/10.1186/1471-2148-14-78

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101840/
https://www.ncbi.nlm.nih.gov/pubmed/24716445
http://dx.doi.org/10.1186/1471-2148-14-78

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