Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection

Hypersensitivity of epidermal melanocytes to oxidative stress is known to contribute to vitiligo pathogenesis. Molecular mechanisms that connect melanocyte redox homeostasis to the complex disease phenotype are not fully understood. Jian et al. show that vitiligo melanocytes have impaired Nrf2-ARE s...

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Detalles Bibliográficos
Autores principales: Qiu, Lei, Song, Zhiqi, Setaluri, Vijayasaradhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101905/
https://www.ncbi.nlm.nih.gov/pubmed/25029322
http://dx.doi.org/10.1038/jid.2014.241
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author Qiu, Lei
Song, Zhiqi
Setaluri, Vijayasaradhi
author_facet Qiu, Lei
Song, Zhiqi
Setaluri, Vijayasaradhi
author_sort Qiu, Lei
collection PubMed
description Hypersensitivity of epidermal melanocytes to oxidative stress is known to contribute to vitiligo pathogenesis. Molecular mechanisms that connect melanocyte redox homeostasis to the complex disease phenotype are not fully understood. Jian et al. show that vitiligo melanocytes have impaired Nrf2-ARE signaling and decreased activation of the antioxidant enzyme system. In patients with vitiligo, higher serum levels of IL-2 correlate with lower levels of HO-1, a product of the Nrf2 target gene.
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spelling pubmed-41019052015-02-01 Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection Qiu, Lei Song, Zhiqi Setaluri, Vijayasaradhi J Invest Dermatol Article Hypersensitivity of epidermal melanocytes to oxidative stress is known to contribute to vitiligo pathogenesis. Molecular mechanisms that connect melanocyte redox homeostasis to the complex disease phenotype are not fully understood. Jian et al. show that vitiligo melanocytes have impaired Nrf2-ARE signaling and decreased activation of the antioxidant enzyme system. In patients with vitiligo, higher serum levels of IL-2 correlate with lower levels of HO-1, a product of the Nrf2 target gene. 2014-08 /pmc/articles/PMC4101905/ /pubmed/25029322 http://dx.doi.org/10.1038/jid.2014.241 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Qiu, Lei
Song, Zhiqi
Setaluri, Vijayasaradhi
Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection
title Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection
title_full Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection
title_fullStr Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection
title_full_unstemmed Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection
title_short Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection
title_sort oxidative stress and vitiligo: the nrf2-are signaling connection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101905/
https://www.ncbi.nlm.nih.gov/pubmed/25029322
http://dx.doi.org/10.1038/jid.2014.241
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AT setalurivijayasaradhi oxidativestressandvitiligothenrf2aresignalingconnection

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