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MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder

Objective. Several studies with contradictory results from different cultures about association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in schizophrenia and bipolar disorders. Little is known about this association in Arab culture and Egypt. So the present study aimed to as...

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Autores principales: El-Hadidy, Mohamed A., Abdeen, Hanaa M., Abd El-Aziz, Sherin M., Al-Harrass, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101969/
https://www.ncbi.nlm.nih.gov/pubmed/25101272
http://dx.doi.org/10.1155/2014/318483
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author El-Hadidy, Mohamed A.
Abdeen, Hanaa M.
Abd El-Aziz, Sherin M.
Al-Harrass, Mohammad
author_facet El-Hadidy, Mohamed A.
Abdeen, Hanaa M.
Abd El-Aziz, Sherin M.
Al-Harrass, Mohammad
author_sort El-Hadidy, Mohamed A.
collection PubMed
description Objective. Several studies with contradictory results from different cultures about association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in schizophrenia and bipolar disorders. Little is known about this association in Arab culture and Egypt. So the present study aimed to assess the association of MTHFR C677T polymorphism in bipolar disorder (BD) and schizophrenia in comparison to control group. The association between MTHFR C677T polymorphism and the age at onset in schizophrenia or BD was also studied. Methods. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to examine the genotype and allele frequencies of MTHFR C677T polymorphism in 149 healthy subjects and 134 bipolar and 103 schizophrenia patients. Results. In BD and schizophrenia, there was a higher prevalence of MTHFR C677T polymorphism than healthy subjects. Earlier age at onset was found in patients with BD, carrying one copy of the T allele or CT genotypes but not in patients with schizophrenia. Conclusion. The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia.
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spelling pubmed-41019692014-08-06 MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder El-Hadidy, Mohamed A. Abdeen, Hanaa M. Abd El-Aziz, Sherin M. Al-Harrass, Mohammad Biomed Res Int Research Article Objective. Several studies with contradictory results from different cultures about association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in schizophrenia and bipolar disorders. Little is known about this association in Arab culture and Egypt. So the present study aimed to assess the association of MTHFR C677T polymorphism in bipolar disorder (BD) and schizophrenia in comparison to control group. The association between MTHFR C677T polymorphism and the age at onset in schizophrenia or BD was also studied. Methods. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to examine the genotype and allele frequencies of MTHFR C677T polymorphism in 149 healthy subjects and 134 bipolar and 103 schizophrenia patients. Results. In BD and schizophrenia, there was a higher prevalence of MTHFR C677T polymorphism than healthy subjects. Earlier age at onset was found in patients with BD, carrying one copy of the T allele or CT genotypes but not in patients with schizophrenia. Conclusion. The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia. Hindawi Publishing Corporation 2014 2014-07-03 /pmc/articles/PMC4101969/ /pubmed/25101272 http://dx.doi.org/10.1155/2014/318483 Text en Copyright © 2014 Mohamed A. El-Hadidy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
El-Hadidy, Mohamed A.
Abdeen, Hanaa M.
Abd El-Aziz, Sherin M.
Al-Harrass, Mohammad
MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder
title MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder
title_full MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder
title_fullStr MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder
title_full_unstemmed MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder
title_short MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder
title_sort mthfr gene polymorphism and age of onset of schizophrenia and bipolar disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101969/
https://www.ncbi.nlm.nih.gov/pubmed/25101272
http://dx.doi.org/10.1155/2014/318483
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