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A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel
Recent X-ray crystal structures of the two-pore domain (K2P) family of potassium channels have revealed a unique structural architecture at the point where the cytoplasmic bundle-crossing gate is found in most other tetrameric K(+) channels. However, despite the apparently open nature of the inner p...
Autores principales: | Aryal, Prafulla, Abd-Wahab, Firdaus, Bucci, Giovanna, Sansom, Mark S. P., Tucker, Stephen J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102122/ https://www.ncbi.nlm.nih.gov/pubmed/25001086 http://dx.doi.org/10.1038/ncomms5377 |
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