Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

Rabex-5 and Rabaptin-5 function together to activate Rab5 and further promote early endosomal fusion in endocytosis. The Rabex-5 GEF activity is autoinhibited by the Rabex-5 CC domain (Rabex-5CC) and activated by the Rabaptin-5 C2-1 domain (Rabaptin-5C21) with yet unknown mechanism. We report here t...

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Detalles Bibliográficos
Autores principales: Zhang, Zhe, Zhang, Tianlong, Wang, Shanshan, Gong, Zhou, Tang, Chun, Chen, Jiangye, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102244/
https://www.ncbi.nlm.nih.gov/pubmed/24957337
http://dx.doi.org/10.7554/eLife.02687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102244/
https://www.ncbi.nlm.nih.gov/pubmed/24957337
http://dx.doi.org/10.7554/eLife.02687

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