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Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

Rabex-5 and Rabaptin-5 function together to activate Rab5 and further promote early endosomal fusion in endocytosis. The Rabex-5 GEF activity is autoinhibited by the Rabex-5 CC domain (Rabex-5CC) and activated by the Rabaptin-5 C2-1 domain (Rabaptin-5C21) with yet unknown mechanism. We report here t...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhe, Zhang, Tianlong, Wang, Shanshan, Gong, Zhou, Tang, Chun, Chen, Jiangye, Ding, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102244/ https://www.ncbi.nlm.nih.gov/pubmed/24957337 http://dx.doi.org/10.7554/eLife.02687

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