Knock-In Reporter Mice Demonstrate that DNA Repair by Non-homologous End Joining Declines with Age

Accumulation of genome rearrangements is a characteristic of aged tissues. Since genome rearrangements result from faulty repair of DNA double strand breaks (DSBs), we hypothesized that DNA DSB repair becomes less efficient with age. The Non-Homologous End Joining (NHEJ) pathway repairs a majority o...

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Detalles Bibliográficos
Autores principales: Vaidya, Amita, Mao, Zhiyong, Tian, Xiao, Spencer, Brianna, Seluanov, Andrei, Gorbunova, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102425/
https://www.ncbi.nlm.nih.gov/pubmed/25033455
http://dx.doi.org/10.1371/journal.pgen.1004511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102425/
https://www.ncbi.nlm.nih.gov/pubmed/25033455
http://dx.doi.org/10.1371/journal.pgen.1004511

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