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Knock-In Reporter Mice Demonstrate that DNA Repair by Non-homologous End Joining Declines with Age
Accumulation of genome rearrangements is a characteristic of aged tissues. Since genome rearrangements result from faulty repair of DNA double strand breaks (DSBs), we hypothesized that DNA DSB repair becomes less efficient with age. The Non-Homologous End Joining (NHEJ) pathway repairs a majority o...
Autores principales: | Vaidya, Amita, Mao, Zhiyong, Tian, Xiao, Spencer, Brianna, Seluanov, Andrei, Gorbunova, Vera |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102425/ https://www.ncbi.nlm.nih.gov/pubmed/25033455 http://dx.doi.org/10.1371/journal.pgen.1004511 |
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