Use of Physiologically-Based Pharmacokinetic Modeling to Simulate the Profiles of 3-Hydroxybenzo(a)pyrene in Workers Exposed to Polycyclic Aromatic Hydrocarbons

Biomathematical modeling has become an important tool to assess xenobiotic exposure in humans. In the present study, we have used a human physiologically-based pharmacokinetic (PBPK) model and an simple compartmental toxicokinetic model of benzo(a)pyrene (BaP) kinetics and its 3-hydroxybenzo(a)pyren...

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Detalles Bibliográficos
Autores principales: Heredia Ortiz, Roberto, Maître, Anne, Barbeau, Damien, Lafontaine, Michel, Bouchard, Michèle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102510/
https://www.ncbi.nlm.nih.gov/pubmed/25032692
http://dx.doi.org/10.1371/journal.pone.0102570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102510/
https://www.ncbi.nlm.nih.gov/pubmed/25032692
http://dx.doi.org/10.1371/journal.pone.0102570

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