Pharmacologic Inhibition of Sphingomyelin Synthase (SMS) Activity Reduces Apolipoprotein-B Secretion from Hepatocytes and Attenuates Endotoxin-Mediated Macrophage Inflammation

Sphingomyelin synthase (SMS) plays an important role in plasma atherogenic lipoprotein metabolism, inflammation, and the development of atherosclerosis. To understand whether the impaired apoB secretion and inflammation response is a direct result from lack of SMS activity, in this study, we prepare...

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Detalles Bibliográficos
Autores principales: Lou, Bin, Dong, Jibin, Li, Yali, Ding, Tingbo, Bi, Tingting, Li, Yue, Deng, Xiaodong, Ye, Deyong, Jiang, Xian-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102531/
https://www.ncbi.nlm.nih.gov/pubmed/25032960
http://dx.doi.org/10.1371/journal.pone.0102641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102531/
https://www.ncbi.nlm.nih.gov/pubmed/25032960
http://dx.doi.org/10.1371/journal.pone.0102641

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