Antitumor Effects of a Sirtuin Inhibitor, Tenovin-6, against Gastric Cancer Cells via Death Receptor 5 Up-Regulation

Up-regulated sirtuin 1 (SIRT1), an NAD(+)-dependent class III histone deacetylase, deacetylates p53 and inhibits its transcriptional activity, leading to cell survival. SIRT1 overexpression has been reported to predict poor survival in some malignancies, including gastric cancer. However, the antitu...

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Detalles Bibliográficos
Autores principales: Hirai, Sachiko, Endo, Shinji, Saito, Rie, Hirose, Mitsuaki, Ueno, Takunori, Suzuki, Hideo, Yamato, Kenji, Abei, Masato, Hyodo, Ichinosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102575/
https://www.ncbi.nlm.nih.gov/pubmed/25033286
http://dx.doi.org/10.1371/journal.pone.0102831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102575/
https://www.ncbi.nlm.nih.gov/pubmed/25033286
http://dx.doi.org/10.1371/journal.pone.0102831

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